师资队伍
杜晓娟教授
一、联系方式：
电话：010-82801547（实验室）
Email: duxiaojuan100@bjmu.edu.cn
二、主要工作简历：
2011.08-今：北京大学基础医学院，细胞生物学系，教授
2001.10-2011.07：北京大学基础医学院，细胞生物学系，副教授
1995.10-1998.06：首都儿科研究所，生化与免疫，副研究员
1993.10-1995.09：首都儿科研究所，生化与免疫，助理研究员
1991.09-1993.09：首都儿科研究所，生化与免疫，实习研究员
三、教育经历：
1998.07-2001.07：德国Freiburg大学，生物学，博士
1988.09-1991.07：首都儿科研究所，生化与免疫，硕士
1982.09-1988.07：北京医科大学，临床医学，本科
四、研究方向：
细胞核仁蛋白及RNA在肿瘤进展中的作用及机制研究
五、主要研究内容：
1.探索细胞在应激状态下，包括DNA损伤或营养缺乏等，核仁蛋白决定细胞命运的作用和机制。主要包括：在细胞有丝分裂、DNA损伤和能量应激时，核仁蛋白通过调控纺锤体形成、核糖体发生、自噬、能量代谢重编程以及DNA损伤修复等过程对细胞命运的决定作用和作用机制，为理解肿瘤发生核进展及肿瘤治疗提供科学依据和参考。2.研究核仁RNA（包括pre-rRNA和snoRNA）调控有丝分裂的作用和机理。
六、承担的研究项目：
主持国家自然科学基金共10项、国家863计划项目1项、北京市教育委员会科技成果转化与产业化项目1项；北京市自然科学基金1项；参与973项目2项、创新团体3项。
七、主要发表文章：（#第一作者，*责任作者）
1. Yang Jiang, Shiqi Sun, Xiaofeng Liu, Kunqi Su, Chunfeng Zhang, Peipei Zhang, Zhuochen Zhao, Ya Su, Chang Wang, Xiaojuan Du*，U3 snoRNA inter-regulates with DDX21 in the perichromosomal region to control mitosis. Cell Death Dis. 2024 May 17;15(5):342. doi: 10.1038/s41419-024-06725-3.
2. Yang Yang, Pengwei Ren, Xiaofeng Liu, Xiaoyan Sun, Chunfeng Zhang, Xiaojuan Du*, Baocai Xing*. PPP1R26 drives hepatocellular carcinoma progression by controlling glycolysis and epithelial-mesenchymal transition. J Exp. Clin. Cancer Res. 2022, 41 （1）:101. DOI : 10.1186/s13046-022-02302-8.
3. Jiaojiao Zheng#, Yuqin Tan#, Xiaofeng Liu, Chunfeng Zhang, Kunqi Su, Yang Jiang, Jianyuan Luo, Li Li* and Xiaojuan Du*. NAT10 regulates mitotic cell fate by acetylating Eg5 to control bipolar spindle assembly and chromosome segregation. Cell Death Differ. 2022, 29(4) :846-860. doi: 10.1038/s41418-021-00899-5.
4. Xiaofeng Liu*, Kunqi Su, Xiaoyan Sun, Yang Jiang, Lijun Wang, Chenyu Hu, Chunfeng Zhang, Min Lu, Xiaojuan Du* and Baocai Xing*. Sec62 promotes stemness and chemoresistance of human colorectal cancer through activating Wnt/β-catenin pathway. J Exp. Clin. Cancer Res. 2021, 40(1):132.
5. Jiaojiao Zheng, Chunfeng Zhang, Yuan Li, Yang Jiang, Baocai Xing*, and Xiaojuan Du*. p21-activated kinase 6 controls mitosis and hepatocellular carcinoma progression by regulating Eg5. BBA Mol Cell Res., 2021;1868(2):118888. doi: 10.1016/j.bbamcr.2020.118888.
6. Yuan Li#, Ling Wang#, Xiaofeng Liu, Chunfeng Zhang, Xiaojuan Du*, Baocai Xing*. NIR promotes progression of colorectal cancer through regulating RB. BBA Mol. Cell Res. 2021; 1868(1):118856. doi: 10.1016/j.bbamcr.2020.118856. (#First authors)
7. Zhenzhen Liu, Xiaofeng Liu, Yuan Li, Pengwei Ren, Chunfeng Zhang, Lijun Wang, Xiaojuan Du*, Baocai Xing*. MiR-6716-5p promotes metastasis of colorectal cancer through downregulating NAT10 expression. Cancer Management and Research. 2019, 11:5317-5332.
8. Pengwei Ren, Xiaoyan Sun, Chunfeng Zhang, Ling Wang, Baocai Xing, Xiaojuan Du*. Human UTP14a promotes angiogenesis through upregulating PDGFA expression in colorectal cancer. Biochem. Biophys. Res. Commun. 2019, 512(4):871-876.
9. Jingyi Zhang#, Pengwei Ren#, Da Xu#, Xiaofeng Liu, Zhenzhen Liu, Chunfeng Zhang, Yuan Lia, Lijun Wanga, Xiaojuan Du* and Baocai Xing*. Human UTP14a promotes colorectal cancer progression by forming a positive regulation loop with c-Myc. Cancer Letters . 2019, 440-441 :106-115.
10. Xiaofeng Liu, Shiying Cai, Chunfeng Zhang, Zhenzhen Liu, Jianyuan Luo, Baocai Xing* and Xiaojuan Du*. Deacetylation of NAT10 by Sirt1 promotes the transition from rRNA biogenesis to autophagy upon energy stress. Nucl Acids Res. , 2018 Oct 12;46(18):9601-9616.
11. Tong Zheng, Min Lu, Ting Wang, Chunfeng Zhang, Xiaojuan Du*. NRBE3 promotes metastasis of breast cancer by down-regulating E-cadherin expression. BBA Mol Cell Res. 2018, 12(1865) : 1869-1877.
12. Huijiao Liu#, Jiangnan Wang#, Yun Liu, Min Lu, Lelin Hu, Chunfeng Zhang, Baocai Xing and Xiaojuan Du*. Human U3 protein14a is a novel type ubiquitin ligase that binds RB and promotes RB degradation depending on a Leucine-rich region. BBA Mol Cell Res. , 2018, 1865 :1611-1620.
13. Yuqin Tan, Jiaojiao Zheng, Xiaofeng Liu, Min Lu, Chunfeng Zhang, Baocai Xing, Xiaojuan Du*, Loss of nucleolar localization of NAT10 promotes cell migration and invasion in hepatocellular carcinoma, Biochem. Biophys. Res. Commun. 2018, 499: 1032-1038.
14. Teng Ma, Chenxi Lu, Yafei Guo, Chunfeng Zhang, Xiaojuan Du*. Human U3 protein 14a plays an anti-apoptotic role in cancer cells. Biol. Chem. 2017, 398(11):1247-1257.
15. Shiying Cai, Xiaofeng Liu, Chunfeng Zhang, Baocai Xing, Xiaojuan Du*. Autoacetylation of NAT10 is critical for its function in rRNA transcription activation. Biochem. Biophys. Res. Commun. 2017, 483: 624-629.
16. Xiaofeng Liu, Yuqin Tan, Chunfeng Zhang, Ying Zhang, Liangliang Zhang, Pengwei Ren, Hongkui Deng, Jianyuan Luo, Yang Ke, Xiaojuan Du*. NAT10 regulates p53 activation through acetylating p53 at K120 and ubiquitinating Mdm2. EMBO Rep. 2016, 17(3): 349-366.
17. Yingshuang Wang, Zongfang Zheng, Jingyi Zhang, You Wang, Ruirui Kong, Jiangying Liu, Ying Zhang, Hongkui Deng, Xiaojuan Du*, Yang Ke*. A novel retinoblastoma protein (RB) E3 ubiquitin Ligase (NRBE3) Promotes RB degradation and is transcriptionally regulated by E2F1 transcription factor. J Biol Chem. 2015, 290(47): 28200-13.
18. Ke-Min Jin, Min Lu, Fang-Fang Liu, Jin Gu, Xiao-Juan Du*, Bao-Cai Xing*. N-WASP is highly expressed in hepatocellular carcinoma and associated with poor prognosis. Surgery. 2013, 153: 518-25.
19. Jun-Min Song, Min Lu, Fang-Fang Liu, Xiao-Juan Du*, Bao-Cai Xing*. AIB1 as an independent prognostic marker in hepatocellular carcinoma after Hepatic Resection. J Gastrointest Surg . 2012, 16: 356-360.
20. Ruirui Kong, Liangliang Zhang, Lelin Hu, Qunhui Peng, Wei Han, Xiaojuan Du*, Yang Ke*. hALP, A novel t-UTP, activates polymerase I transcription by binding and acetylating the upstream binding factor. J Biol Chem. 2011, 286(9): 7139-48.
21. Lelin Hu, Jiangnan Wang, Yun Liu, Ying Zhang, Liangliang Zhang, Ruirui Kong, Zongfang Zheng, Xiaojuan Du*, Yang Ke*. A small ribosomal subunit (SSU) processome component, the human U three protein 14a binds p53 and promotes p53 degradation. J Biol Chem. 2011, 286(4): 3119-28.