一、个人简介：

1997.9 – 2002.7 四川大学华西医学中心  学士

2002.9 – 2007.7 北京大学医学部  博士

2007.8 – 2012.7 北京大学 细胞生物学系讲师

2012.8 – 至今北京大学 细胞生物学系副教授

二、研究方向：

肿瘤细胞生物学

三、代表性研究论文：

1. Song Q, Liu T, Yang H, Bai Y. Innovative Comprehensive Experiments to Study the Morphological Changes of Apoptotic Cells for Undergraduate Education.  Biochem Mol Biol Educ. 2019;47(3):348-354.

2. Zhu B, Yan K, Li L, Lin M, Zhang S, He Q, Zheng D, Yang H, Shao G. K63-linked ubiquitination of FANCG is required for its association with the Rap80-BRCA1 complex to modulate homologous recombination repair of DNA interstrand crosslinks.  Oncogene.  2015 28;34(22):2867-78.

3. Yan K, Li L, Wang X, Hong R, Zhang Y, Yang H, Lin M, Zhang S, He Q, Zheng D, Tang J, Yin Y, Shao G. The deubiquitinating enzyme complex BRISC is required for proper mitotic spindle assembly in mammalian cells.  J Cell Biol. 2015 20;210(2):209-24.

4. Zhai G, Yan K, Ji X, Xu W, Yang J, Xiong F, Su J, McNutt MA, Yang H. LAPTM4B allele *2 is a marker of poor prognosis for gallbladder carcinoma.  PLoS One. 2012; 7(9):e45290.

5. Yang H, Zhai G, Ji X, Xiong F, Su J, McNutt MA. LAPTM4B allele *2 is a marker of poor prognosis following hepatic tumor resection for hepatocellular carcinoma.  PLoS One. 2012; 7(4):e34984.

6. Yang H, Zhai G, Ji X, Xiong F, Su J, McNutt MA. Correlation of LAPTM4B polymorphisms with gallbladder carcinoma susceptibility in Chinese patients.  Med Oncol. 2012 Dec; 29(4):2809-13

7. Zhai G, Yang H, Ji X, Xiong F, Su J, McNutt MA, Li X. Correlation of LAPTM4B polymorphisms with hepatocellular carcinoma in Chinese patients. Med Oncol. 2012;29(4):2744-9.

8. Yang H, Zhai G, Ji X, Su J, Lin M. Reduced expression of argininosuccinate lyase is closely associated with post-resectional survival in hepatocellular carcinoma- an immunohistochemistry study of 61 cases.  Appl Immunohistochem Mol Morphol.  2012;20(6):602-6.

9. Yang H, Lin M, Xiong F, Yang Y, Nie X, McNutt MA, Zhou R. Combined lysosomal protein transmembrane 4 beta -35 and argininosuccinate synthetase expression predicts clinical outcome in hepatocellular carcinoma patients.  Surg Today.  2011;41(6):810-7.

10. Li L, Shan Y, Yang H, Zhang S, Lin M, Zhu P, Chen XY, Yi J, McNutt MA, Shao GZ, Zhou RL. Upregulation of LAPTM4B-35 promotes malignant transformation and tumorigenesis in L02 human liver cell line.  Anat Rec (Hoboken).  2011;294(7):1135-42.

11. Yang H, Xiong F, Wei X, Yang Y, McNutt MA, Zhou R. Overexpression of LAPTM4B-35 promotes growth and metastasis of hepatocellular carcinoma in vitro and in vivo.  Cancer Lett . 2010; 294(2):236-44.

12. Yang H, Xiong F, Qi R, Liu Z, Lin M, Rui J, Su J, Zhou R. LAPTM4B-35 is a novel prognostic factor of hepatocellular carcinoma.  J Surg Oncol. 2010; 101(5):363-9.

13. Yang H, Xiong F, Lin M, Yang Y, Nie X, Zhou R. LAPTM4B-35 overexpression is a risk factor for tumor recurrence and poor prognosis in hepatocellular carcinoma.  J Cancer Res Clin Oncol. 2010; 136(2):275-81.

14. Meng FL, Yin MZ, Song HT, Yang H, Lou G, Zhou RL. LAPTM4B-35 overexpression is an independent prognostic marker in endometrial carcinoma. Int J Gynecol Cancer. 2010 ;20(5):745-50.

15. Zhou L, He XD, Yu JC, Zhou RL, Yang H, Qu Q, Rui JA. Overexpression of LAPTM4B promotes growth of gallbladder carcinoma cells in vitro.  Am J Surg. 2010;199(4):515-21.

16. Liu X, Xiong F, Wei X, Yang H, Zhou R. LAPTM4B-35, a novel tetratransmembrane protein and its PPRP motif play critical roles in proliferation and metastatic potential of hepatocellular carcinoma cells.  Cancer Sci.  2009;100(12):2335-40.

四、联系方式：

Email: yanghua@bjmu.edu.cn