一、个人简介：

1993 - 1998年：北京大学医学部，学士

1998 - 2003年：北京大学医学部，博士

2010 - 2011年：美国国立卫生研究院（NIH）衰老研究所，访问学者

2003 - 至今：北京大学基础医学院细胞生物学系，北京大学干细胞研究中心，讲师、副教授、教授、博士生导师

二、研究方向：

干细胞生物学与肿瘤免疫治疗。

三、主持国家重点基础研究发展计划项目1项，国家自然科学基金7项，北京市自然科学基金3项；参与创新团体1项。

四、代表性研究论文：

1. Zhao J^#, Dong J^#, Deng C^#, Zhang Q, Sun S, Li H, Bai Y*, Deng H*. Enhancing T cell anti-tumor efficacy with a PD1-TIGIT chimeric immune-checkpoint switch receptor. Oncoimmunology. 2023, 12(1):2265703.

2. Jiang M, Song Y, Chen X, Wen J, Zhu M, Wei M, Lan F, Cui M*, Bai Y*. COX6A2 deficiency leads to cardiac remodeling in human pluripotent stem cell-derived cardiomyocytes. Stem Cell Research & Therapy, 14, 357 (2023).

3. Liu B^#, Chen S^#, Xu Y^#, Lyu Y^#, Wang J, Du Y, Sun Y, Liu H, Zhou H, Lai W, Xue A, Yin M, Li C, Bai Y*, Xu J*, Deng H*. Chemically defined and xeno-free culture condition for human extended pluripotent stem cells.  Nature Communications,  2021, 12(1): 3017.

4. Deng C^#, Zhao J^#, Zhou S, Dong J, Cao J, Gao J, Bai Y*, Deng H*. The Vascular Disrupting Agent CA4P Improves the Antitumor Efficacy of CAR-T Cells in Preclinical Models of Solid Human Tumors. Molecular Therapy. 2020, 28(1): 75-88.

5. Luo Z^#, Liu Z^#, Liang Z, Pan J, Xu J, Dong J, Bai Y*, Deng H*, Wei S*.Injectable Porous Microchips with Oxygen Reservoirs and an Immune-Niche Enhance the Efficacy of CAR T Cell Therapy in Solid Tumors. ACS Applied Materials & Interfaces. 2020, 12(51): 56712-56722.

6. Li H^#, Zhao C^#, Xu J, Xu Y, Cheng C, Liu Y, Wang T, Du Y, Xie L, Zhao J, Han Y, Wang X, Bai Y*, Deng H*. Rapid generation of gene-targeted EPS-derived mouse models through tetraploid complementation. Protein Cell, 2019, 10(1): 20-30.

7. Zhang S^#, Lin X^#, Li G, Shen X, Niu D, Lu G, Fu X, Chen Y, Cui M*, Bai Y*. Knockout of Eva1a leads to rapid development of heart failure by impairing autophagy. Cell Death & Disease, 2017, 8(2): e2586.

8. Zhong L^#, Zhou J^#, Chen X, Liu J, Liu Z, Chen Y, Bai Y*. Quantitative proteomics reveals EVA1A-related proteins involved in neuronal differentiation. Proteomics, 2017, 17(5). doi: 10.1002/pmic.201600294.

9. Shen X^#, Kan S^#, Liu Z, Lu G, Zhang X, Chen Y, Bai Y*. EVA1A inhibits GBM cell proliferation by inducing autophagy and apoptosis. Experimental Cell Research, 2017, 352(1):130-138.

10. Li M^#, Lu G^#, Hu J^#, Shen X, Ju J, Gao Y, Qu L, Xia Y, Chen Y*, Bai Y*. EVA1A/TMEM166 Regulates Embryonic Neurogenesis by Autophagy. Stem Cell Reports, 2016, 6(3): 396-410.

11. Shen X, Kan S, Hu J, Li M, Lu G, Zhang M, Zhang S, Hou Y, Chen Y*, Bai Y*. EMC6/TMEM93 suppresses glioblastoma proliferation by modulating autophagy. Cell Death & Disease, 2016, 7: e2043.

12. Bai Y*, Kan S, Zhou S, Wang Y, Xu J, Cooke JP*, Wen J*, Deng H*. Enhancement of the in vivo persistence and antitumor efficacy of CD19 chimeric antigen receptor T cells through the delivery of modified TERT mRNA. Cell Discovery, 2015,1,15040.

13. Bai Y, Lathia JD, Zhang P, Flavahan W, Rich JN, Mattson MP. Molecular targeting of TRF2 suppresses the growth and tumorigenesis of glioblastoma stem cells. Glia, 2014, 62(10):1687-98.

14. Meng Z, Li M, He Q, Jiang S, Zhang X, Xiao J, Bai Y*. Ectopic expression of human angiopoietin-1 promotes functional recovery and neurogenesis after focal cerebral ischemia. Neuroscience, 2014, 267: 135-46.

五、联系方式：

电话：010-82801495

Email: baiyun@bjmu.edu.cn